Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 11/20 | 0.81 |
| ▸ | TLR2 | O60603 | 11/20 | 0.81 |
| ▸ | MAOA | P21397 | 10/20 | 0.81 |
| ▸ | MAOB | P27338 | 10/20 | 0.81 |
| ▸ | FBP1 | P09467 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5720900 | 1.00 | TLR4 (0.81) | TLR4TLR2MAOAMAOBFBP1 | |
| SCHEMBL510222 | 0.90 | MAOA (1.00) | TLR4TLR2MAOAMAOBLCK | |
| SCHEMBL510223 | 0.90 | MAOA (1.00) | TLR4TLR2MAOAMAOBLCK | |
| SCHEMBL20816026 | 0.80 | MAOA (0.77) | TLR4TLR2MAOAMAOBLCK | |
| SCHEMBL3637672 | 0.80 | FBP1 (0.52) | TLR4TLR2MAOAMAOBFBP1 | |
| SCHEMBL1967344 | 0.78 | TLR4 (0.67) | TLR4TLR2MAOAMAOBFBP1 | |
| SCHEMBL1967341 | 0.78 | TLR4 (0.67) | TLR4TLR2MAOAMAOBFBP1 | |
| SCHEMBL4747135 | 0.78 | MAPT (0.55) | TLR4TLR2MAOAMAOB | |
| SCHEMBL4619916 | 0.77 | TLR4 (0.70) | TLR4TLR2MAOAMAOBFBP1 | |
| SCHEMBL4619911 | 0.77 | TLR4 (0.70) | TLR4TLR2MAOAMAOBFBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1618089-A1 | METHOD OF PREPARING A RING COMPOUND HAVING TWO ADJACENT CHIRAL CENTERS | ICOS CORPORATION (US) | 2006-01-25 | — | — | EP | disclosed |
| WO-2004096764-A1 | METHOD OF PREPARING A RING COMPOUND HAVING TWO ADJACENT CHIRAL CENTERS | ICOS CORPORATION (US) | 2004-11-11 | — | — | WO | disclosed |