Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.43 |
| ▸ | FABP1 | P07148 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3639218 | 0.89 | KDR (0.41) | CRHBPCRHR2KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL3636294 | 0.86 | CDK8 (0.53) | THRBNR1H4FABP1 | |
| SCHEMBL3641158 | 0.80 | MEN1 (0.47) | KMT2ASMN1; SMN2MEN1MAPTHPGD | |
| SCHEMBL3638529 | 0.80 | BRAF (0.57) | FFAR1 | |
| SCHEMBL2337545 | 0.79 | MAPT (0.54) | FFAR1CRHBPCRHR2KMT2ASMN1; SMN2 | |
| SCHEMBL2334149 | 0.79 | POLB (0.47) | FFAR1KMT2ASMN1; SMN2MEN1MAPT | |
| SCHEMBL2336817 | 0.78 | MEN1 (0.52) | FFAR1CRHBPCRHR2KMT2ASMN1; SMN2 | |
| SCHEMBL3640649 | 0.75 | BRAF (0.47) | MAPT | |
| SCHEMBL2862074 | 0.75 | CDK8 (0.51) | FFAR1KMT2ASMN1; SMN2MEN1MAPT | |
| SCHEMBL2862069 | 0.75 | CDK8 (0.51) | FFAR1KMT2ASMN1; SMN2MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2162445-A1 | HETEROBICYCLIC COMPOUNDS AS KINASE INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2010-03-17 | — | — | EP | disclosed |
| WO-2008150015-A1 | HETEROBICYCLIC COMPOUNDS AS KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-12-11 | — | — | WO | disclosed |