Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 15/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.46 |
| ▸ | FABP1 | P07148 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3640649 | 0.88 | BRAF (0.47) | CDK8 | |
| SCHEMBL3638532 | 0.86 | FFAR1 (0.47) | THRBNR1H4FABP1 | |
| SCHEMBL3641158 | 0.82 | MEN1 (0.47) | CDK8NR1H4 | |
| SCHEMBL2335120 | 0.80 | FNTA (0.44) | THRBNR1H4 | |
| SCHEMBL2857455 | 0.79 | BRAF (0.68) | CDK8 | |
| SCHEMBL2334149 | 0.77 | POLB (0.47) | — | |
| SCHEMBL2851251 | 0.76 | CDK8 (0.52) | CDK8 | |
| SCHEMBL2338143 | 0.76 | KMT2A (0.58) | NR1H4 | |
| SCHEMBL2857312 | 0.75 | CDK8 (0.79) | CDK8 | |
| SCHEMBL3639218 | 0.75 | KDR (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2162445-A1 | HETEROBICYCLIC COMPOUNDS AS KINASE INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2010-03-17 | — | — | EP | disclosed |
| WO-2008150015-A1 | HETEROBICYCLIC COMPOUNDS AS KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-12-11 | — | — | WO | disclosed |