Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.47 |
| ▸ | CDK8 | P49336 | 10/20 | 0.47 |
| ▸ | KDR | P35968 | 4/20 | 0.43 |
| ▸ | TEK | Q02763 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3636294 | 0.88 | CDK8 (0.53) | CDK8 | |
| SCHEMBL3639218 | 0.87 | KDR (0.41) | BRAFKDRTEKKDM4EMAPT | |
| SCHEMBL3640647 | 0.80 | BRAF (0.72) | BRAF | |
| SCHEMBL3636051 | 0.77 | SMN1; SMN2 (0.50) | BRAFMAPT | |
| SCHEMBL3638532 | 0.75 | FFAR1 (0.47) | MAPT | |
| SCHEMBL2860429 | 0.74 | CDK8 (0.56) | CDK8 | |
| SCHEMBL2335120 | 0.73 | FNTA (0.44) | KDM4EMAPT | |
| SCHEMBL3641158 | 0.73 | MEN1 (0.47) | CDK8MAPT | |
| SCHEMBL2338143 | 0.72 | KMT2A (0.58) | MAPT | |
| SCHEMBL2334149 | 0.71 | POLB (0.47) | BRAFKDRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2162445-A1 | HETEROBICYCLIC COMPOUNDS AS KINASE INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2010-03-17 | — | — | EP | disclosed |
| WO-2008150015-A1 | HETEROBICYCLIC COMPOUNDS AS KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-12-11 | — | — | WO | disclosed |