Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.48 |
| ▸ | PREP | P48147 | 3/20 | 0.47 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KLK7 | P49862 | 1/20 | 0.43 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3637452 | 0.90 | FKBP1A (0.48) | ACE2PREPFKBP1ATMEM97SIGMAR1 | |
| SCHEMBL6475398 | 0.89 | PREP (0.49) | ACE2PREPNPSR1TSHRL3MBTL1 | |
| SCHEMBL6475389 | 0.89 | PREP (0.49) | ACE2PREPNPSR1TSHRL3MBTL1 | |
| SCHEMBL6484219 | 0.89 | PREP (0.49) | ACE2PREPNPSR1TSHRL3MBTL1 | |
| SCHEMBL3354292 | 0.84 | PREP (0.54) | ACE2PREPFKBP1ATMEM97SIGMAR1 | |
| SCHEMBL29560191 | 0.82 | SMN1; SMN2 (0.45) | PREPNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14646665 | 0.81 | TMEM97 (0.56) | ACE2PREPFKBP1ATMEM97SIGMAR1 | |
| SCHEMBL19621551 | 0.81 | TMEM97 (0.56) | ACE2PREPFKBP1ATMEM97SIGMAR1 | |
| SCHEMBL31153718 | 0.81 | TSHR (0.46) | ACE2PREPFKBP1ANPSR1SMN1; SMN2 | |
| SCHEMBL7598362 | 0.80 | TMEM97 (0.51) | ACE2PREPFKBP1ATMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155678-A1 | NEW BRADYKININ B1 ANTAGONISTS | EVOTEC Neurosciences GmbH (DE) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008125570-A1 | NEW BRADYKININ B1 ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2008-10-23 | — | — | WO | disclosed |