Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.58 |
| ▸ | MYC | P01106 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3639905 | 0.88 | L3MBTL1 (0.65) | GAAKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL546063 | 0.86 | ALDH1A1 (0.78) | GAAKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL32660033 | 0.83 | GAA (0.72) | GAAKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL22767195 | 0.83 | GAA (1.00) | GAAKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL20597980 | 0.83 | GAA (0.72) | GAAKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL11287512 | 0.83 | GAA (0.72) | GAAKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL30501408 | 0.83 | GAA (0.72) | GAAKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL3512031 | 0.82 | GAA (0.64) | GAAKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL7671473 | 0.82 | SMN1; SMN2 (0.79) | GAAKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL6414184 | 0.81 | ALDH1A1 (0.74) | GAAKDM4EALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176231-A1 | SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2010-04-21 | — | — | EP | disclosed |
| WO-2009013126-A1 | SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-01-29 | — | — | WO | disclosed |