Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 3/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | GPX4 | P36969 | 3/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | TEK | Q02763 | 1/20 | 0.35 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3633316 | 0.84 | PIK3CD (0.34) | KITGPX4GRIN1GRIN2BEGFR | |
| SCHEMBL3634899 | 0.82 | LMNA (0.44) | EGFRERBB2IGF1RTEKPSEN1 | |
| SCHEMBL3635336 | 0.82 | KCNH2 (0.42) | KCNH2GRIN2BMEN1KMT2APSEN1 | |
| SCHEMBL3638040 | 0.80 | OGA (0.44) | GPX4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3636918 | 0.79 | MAP4K1 (0.44) | KITCDK9 | |
| SCHEMBL3638880 | 0.78 | PSEN1 (0.38) | KITPLK1GPX4EGFRERBB2 | |
| SCHEMBL1040502 | 0.78 | PSEN1 (0.56) | KCNH2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3406352 | 0.75 | BRAF (0.46) | KCNH2EGFRPSEN1PSEN2APH1B | |
| SCHEMBL3640777 | 0.74 | PSEN1 (0.52) | KITPLK1MEN1KMT2AEGFR | |
| SCHEMBL2329626 | 0.73 | MAPT (0.45) | KCNH2GRIN2BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155740-A1 | HETARYLANILINES AS MODULATORS FOR AMYLOID BETA | F. Hoffmann-Roche AG (CH) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008138753-A1 | HETARYLANILINES AS MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-20 | — | — | WO | disclosed |