Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 9/20 | 0.43 |
| ▸ | CTSK | P43235 | 6/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | GPR6 | P46095 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1744011 | 0.85 | CTSS (0.43) | EGLN1CTSSCTSKPARP1DRD1 | |
| Trifluoroacetic Acid SCHEMBL13822271 | 0.80 | GPR6 (0.35) | GPR6L3MBTL1PLCG1 | |
| Trifluoroacetic Acid SCHEMBL25208651 | 0.78 | PARP1 (0.49) | EGLN1CTSSCTSKPARP1 | |
| SCHEMBL7293963 | 0.72 | EGLN1 (0.42) | EGLN1CTSSCTSKPARP1DRD1 | |
| SCHEMBL4791037 | 0.71 | EGLN1 (0.63) | EGLN1PARP1L3MBTL1MMP12HCRTR1 | |
| Trifluoroacetic Acid SCHEMBL20482044 | 0.70 | PARP1 (0.60) | PARP1 | |
| Trifluoroacetic Acid SCHEMBL14638487 | 0.69 | PIN1 (0.48) | — | |
| Trifluoroacetic Acid SCHEMBL14638489 | 0.69 | PIN1 (0.42) | L3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL2500721 | 0.67 | PARP1 (0.46) | EGLN1PARP1L3MBTL1 | |
| SCHEMBL22533810 | 0.66 | EGLN1 (0.57) | EGLN1PARP1DRD1MMP12HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2178873-A1 | 6-PHENYL-1H-IMIDAZO[4,5-C]PYRIDINE-4-CARBONITRILE DERIVATIVES AS CATHEPSIN INHIBITORS | N.V. Organon (NL) | 2010-04-28 | — | — | EP | claimed |
| WO-2009010491-A1 | 6-PHENYL-1H-IMIDAZO[4,5-C]PYRIDINE-4-CARBONITRILE DERIVATIVES AS CATHEPSIN INHIBITORS | N.V. ORGANON (NL) | 2009-01-22 | — | — | WO | claimed |
| EP-2178873-A1 | 6-PHENYL-1H-IMIDAZO[4,5-C]PYRIDINE-4-CARBONITRILE DERIVATIVES AS CATHEPSIN INHIBITORS | N.V. Organon (NL) | 2010-04-28 | — | — | EP | disclosed |
| WO-2009010491-A1 | 6-PHENYL-1H-IMIDAZO[4,5-C]PYRIDINE-4-CARBONITRILE DERIVATIVES AS CATHEPSIN INHIBITORS | N.V. ORGANON (NL) | 2009-01-22 | — | — | WO | disclosed |