Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3511179 | 0.77 | HRH4 (0.36) | HRH4ADRA2CHTR3AGAAKDM4E | |
| SCHEMBL591556 | 0.74 | ADRA2C (0.38) | HRH4ADRA2CHTR3AGAAKDM4E | |
| SCHEMBL589723 | 0.74 | ADRA2C (0.38) | HRH4ADRA2CHTR3AGAAKDM4E | |
| SCHEMBL591108 | 0.74 | ADRA2C (0.38) | HRH4ADRA2CHTR3AGAAKDM4E | |
| SCHEMBL589574 | 0.72 | INSR (0.37) | HRH4ADRA2CHTR3AGAAKDM4E | |
| SCHEMBL3510538 | 0.72 | HRH4 (0.44) | HRH4ADRA2CHTR3AGAAKDM4E | |
| SCHEMBL3512487 | 0.71 | HRH4 (0.51) | HRH4ADRA2CHTR3AGAAKDM4E | |
| SCHEMBL3510642 | 0.71 | KDM4E (0.40) | ADRA2CHTR3AGAAKDM4EMAPT | |
| SCHEMBL3511703 | 0.71 | HRH4 (0.45) | HRH4ADRA2CHTR3AGAAKDM4E | |
| SCHEMBL3512014 | 0.70 | HTR3A (0.46) | HRH4ADRA2CHTR3ARECQLHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176231-A1 | SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2010-04-21 | — | — | EP | disclosed |
| WO-2009013126-A1 | SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-01-29 | — | — | WO | disclosed |