Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 4/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | VEGFA | P15692 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3031283 | 0.80 | EPAS1 (0.33) | EPAS1CYP3A4 | |
| SCHEMBL14920185 | 0.78 | RHEB (0.45) | — | |
| SCHEMBL3023318 | 0.78 | CYP3A4 (0.38) | EPAS1CYP3A4 | |
| SCHEMBL13481896 | 0.77 | CYP3A4 (0.42) | EPAS1CYP3A4 | |
| SCHEMBL3033047 | 0.77 | CYP3A4 (0.38) | EPAS1CYP3A4 | |
| SCHEMBL4754754 | 0.73 | CAMK2A (0.41) | CYP3A4 | |
| SCHEMBL2884075 | 0.72 | EPAS1 (0.40) | EPAS1VEGFA | |
| SCHEMBL13581458 | 0.72 | CYP3A4 (0.34) | CYP3A4 | |
| SCHEMBL2884469 | 0.71 | TSHR (0.32) | CYP3A4 | |
| SCHEMBL4752685 | 0.70 | MEP1B (0.38) | CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166856-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008154271-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-18 | — | — | WO | disclosed |