Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 9/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 5/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4695548 | 0.83 | CCR1 (0.42) | CCR1LMNAMAPTBRD4ALDH1A1 | |
| SCHEMBL4016748 | 0.79 | CCR1 (0.56) | CCR1LMNAMAPTALDH1A1 | |
| SCHEMBL3638408 | 0.79 | CCR1 (0.40) | CCR1LMNAMAPTBRD4 | |
| SCHEMBL4693246 | 0.79 | CCR1 (0.43) | CCR1BRD4ALDH1A1 | |
| SCHEMBL3632086 | 0.78 | CCR1 (0.42) | CCR1LMNAMAPTBRD4 | |
| SCHEMBL3636885 | 0.78 | CCR1 (0.41) | CCR1LMNAMAPTBRD4 | |
| SCHEMBL1639621 | 0.78 | CCR1 (0.65) | CCR1 | |
| SCHEMBL5289677 | 0.78 | CCR1 (0.42) | CCR1LMNAMAPTBRD4 | |
| SCHEMBL3819440 | 0.77 | SIRT6 (0.49) | CCR1LMNAMAPTBRD4ALDH1A1 | |
| SCHEMBL3633791 | 0.76 | CCR1 (0.42) | CCR1LMNAMAPTBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155203-A1 | AZAINDAZOLE COMPOUNDS AND METHODS OF USE | ChemoCentryx Inc (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008147822-A1 | AZAINDAZOLE COMPOUNDS AND METHODS OF USE | CHEMOCENTRYX, INC. (US) | 2008-12-04 | — | — | WO | disclosed |
| EP-1906965-A2 | AZAINDAZOLE COMPOUNDS AND METHODS OF USE | ChemoCentryx Inc (US) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007002293-A2 | AZAINDAZOLE COMPOUNDS AND METHODS OF USE | CHEMOCENTRYX, INC. (US) | 2007-01-04 | — | — | WO | disclosed |