Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.40 |
| ▸ | CHRNG | P07510 | 1/20 | 0.40 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | CHRND | Q07001 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3633304 | 0.86 | PNMT (0.49) | CA2 | |
| SCHEMBL1403495 | 0.82 | CA2 (0.65) | CA2ALDH1A1NPSR1KDM4ECA1 | |
| SCHEMBL15181144 | 0.79 | CA2 (0.46) | CA2ALDH1A1NPSR1KDM4ECA1 | |
| SCHEMBL4685210 | 0.77 | CA2 (0.47) | CA2ALDH1A1NPSR1KDM4ECA1 | |
| SCHEMBL4685207 | 0.77 | CA2 (0.44) | CA2ALDH1A1NPSR1KDM4ECA1 | |
| SCHEMBL2655186 | 0.77 | CA2 (0.44) | CA2ALDH1A1NPSR1KDM4ECA1 | |
| SCHEMBL2164370 | 0.76 | CA2 (0.47) | CA2ALDH1A1NPSR1KDM4ECA1 | |
| SCHEMBL3637432 | 0.75 | IDO1 (0.48) | KDM4EMAPT | |
| SCHEMBL14621890 | 0.75 | ALDH1A1 (0.42) | CA2ALDH1A1NPSR1KDM4ECA1 | |
| SCHEMBL10229485 | 0.75 | ALDH1A1 (0.53) | CA2ALDH1A1KDM4ECA1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155740-A1 | HETARYLANILINES AS MODULATORS FOR AMYLOID BETA | F. Hoffmann-Roche AG (CH) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008138753-A1 | HETARYLANILINES AS MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-20 | — | — | WO | disclosed |