Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.46 |
| ▸ | FKBP1A | P62942 | 4/20 | 0.46 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.45 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | PREP | P48147 | 3/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13567882 | 0.97 | PREP (0.47) | PARP1PREPACE2 | |
| SCHEMBL3636928 | 0.90 | PARP1 (0.46) | TMEM97SIGMAR1FKBP1APARP1PREP | |
| SCHEMBL13567881 | 0.85 | PREP (0.52) | FKBP1APREPACE2 | |
| SCHEMBL6610814 | 0.85 | DAGLA (0.54) | FKBP1AABHD6DAGLAPARP1PRMT5 | |
| SCHEMBL20129716 | 0.85 | DAGLA (0.54) | FKBP1AABHD6DAGLAPARP1PRMT5 | |
| SCHEMBL30872540 | 0.84 | FKBP1A (0.47) | TMEM97SIGMAR1FKBP1AABHD6DAGLA | |
| SCHEMBL10899666 | 0.82 | PREP (0.51) | PREPACE2 | |
| SCHEMBL10899658 | 0.82 | PREP (0.51) | PREPACE2 | |
| SCHEMBL3763846 | 0.82 | PDE8B (0.43) | PREP | |
| SCHEMBL3604619 | 0.82 | FKBP1A (0.51) | TMEM97SIGMAR1FKBP1AABHD6DAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155678-A1 | NEW BRADYKININ B1 ANTAGONISTS | EVOTEC Neurosciences GmbH (DE) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008125570-A1 | NEW BRADYKININ B1 ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2008-10-23 | — | — | WO | disclosed |
| WO-2008125570-A1 | NEW BRADYKININ B1 ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2008-10-23 | — | — | WO | disclosed |