Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.39 |
| ▸ | FEN1 | P39748 | 2/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3640723 | 0.85 | GRM5 (0.43) | GRM5HTR1ADRD2DRD4KDM4E | |
| SCHEMBL20157283 | 0.81 | KDM5A (0.53) | GRM5HTR1ADRD2DRD4TRPV3 | |
| SCHEMBL20140687 | 0.81 | KDM5A (0.53) | GRM5HTR1ADRD2DRD4TRPV3 | |
| SCHEMBL20140593 | 0.79 | HTR1A (0.54) | GRM5HTR1ADRD2DRD4TRPV3 | |
| SCHEMBL3645309 | 0.77 | GRM5 (0.60) | GRM5KDM4EPKMCCNA2CDK2 | |
| SCHEMBL31232914 | 0.76 | GRM5 (0.48) | GRM5HTR1ADRD2DRD4KDM4E | |
| SCHEMBL3001502 | 0.76 | GRM5 (0.48) | GRM5HTR1ADRD2DRD4KDM4E | |
| SCHEMBL31192689 | 0.72 | KDM4E (0.52) | GRM5KDM4EPKMCCNA2CDK2 | |
| SCHEMBL23530033 | 0.71 | TRPV3 (0.54) | TRPV3KDM4EALOX5APFEN1PRMT5 | |
| SCHEMBL29549796 | 0.71 | TRPV3 (0.54) | TRPV3KDM4EALOX5APFEN1PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2178858-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS MGLU5 ANTAGONISTS | Recordati Ireland Limited (IE) | 2010-04-28 | — | — | EP | claimed |
| WO-2009015897-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS MGLU5 ANTAGONISTS | RECORDATI IRELAND LIMITED (IE) | 2009-02-05 | — | — | WO | claimed |