Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 10/20 | 0.45 |
| ▸ | UBE2T | Q9NPD8 | 1/20 | 0.41 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16871130 | 0.75 | CASR (0.46) | CASRL3MBTL1ALDH1A1MEN1MAPT | |
| SCHEMBL16871360 | 0.74 | CASR (0.48) | CASRCYP1A2L3MBTL1CYP3A4CYP2C19 | |
| SCHEMBL5720317 | 0.71 | CASR (0.51) | CASRUBE2TASIC3CYP1A2CYP2D6 | |
| SCHEMBL3117203 | 0.71 | CASR (0.42) | CASRUBE2TASIC3CYP1A2CYP2D6 | |
| SCHEMBL439212 | 0.70 | KIF11 (0.46) | CYP1A2MAPK1CYP2C19ALDH1A1 | |
| SCHEMBL227210 | 0.70 | CASR (0.58) | CASRL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1666355 | 0.70 | CASR (0.50) | CASRUBE2TASIC3CYP1A2CYP2D6 | |
| SCHEMBL3907554 | 0.70 | CASR (0.53) | CASRUBE2TASIC3CYP1A2CYP2D6 | |
| SCHEMBL108180 | 0.70 | CASR (0.58) | CASRL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16871004 | 0.69 | CASR (0.43) | CASRCYP1A2CYP2D6CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176247-A2 | DERIVATIVES OF UREA AND RELATED DIAMINES, METHODS FOR THEIR MANUFACTURE, AND USES THEREFOR | Amgen Inc. (US) | 2010-04-21 | — | — | EP | claimed |
| WO-2009009122-A2 | DERIVATIVES OF UREA AND RELATED DIAMINES, METHODS FOR THEIR MANUFACTURE, AND USES THEREFOR | AMGEN INC. (US) | 2009-01-15 | — | — | WO | claimed |