Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.47 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.46 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.44 |
| ▸ | CASR | P41180 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2337192 | 0.85 | ANPEP (0.51) | KMT2ASMN1; SMN2ALDH1A1CYP3A4MAPK1 | |
| SCHEMBL2336820 | 0.82 | KMT2A (0.40) | KMT2ATSHRPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL20504196 | 0.82 | MAPT (0.46) | LOXL2KMT2ATSHRALDH1A1CYP3A4 | |
| SCHEMBL935891 | 0.82 | LOXL2 (0.47) | LOXL2CYP4F2CYP4A11KMT2ASLC7A5 | |
| SCHEMBL2522006 | 0.81 | LOXL2 (0.46) | LOXL2CYP4F2CYP4A11KMT2ASLC7A5 | |
| SCHEMBL17380991 | 0.81 | LOXL2 (0.44) | LOXL2CYP4F2CYP4A11SLC7A5CASR | |
| SCHEMBL11457916 | 0.81 | HPGD (0.36) | LOXL2KMT2ACASRTSHRPOLB | |
| SCHEMBL20032090 | 0.80 | LOXL2 (0.53) | LOXL2CYP4F2CYP4A11KMT2ASLC7A5 | |
| SCHEMBL10606809 | 0.79 | LOXL2 (0.51) | LOXL2CYP4F2CYP4A11KMT2ASLC7A5 | |
| SCHEMBL28346938 | 0.79 | HDAC4 (0.51) | LOXL2CYP4F2CYP4A11SLC7A5CASR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2162445-A1 | HETEROBICYCLIC COMPOUNDS AS KINASE INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2010-03-17 | — | — | EP | disclosed |
| EP-2049541-A2 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008150015-A1 | HETEROBICYCLIC COMPOUNDS AS KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-12-11 | — | — | WO | disclosed |
| WO-2008016192-A2 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-02-07 | — | — | WO | disclosed |
| EP-0525506-B2 | A process for the alpha-monoalkylation of arylacetonitriles, arylacetoesters and arylacetic acids | TESSENDERLO CHEM NV (BE) | 1999-03-17 | — | — | EP | disclosed |
| US-5278333-A | Heat treatment | TESSENDERLO CHEMIE N.V. (BE) | 1994-01-11 | — | — | US | disclosed |
| EP-0525506-A2 | A process for the alpha-monoalkylation of arylacetonitriles, arylacetoesters and arylacetic acids | TESSENDERLO CHEMIE N.V. (BE) | 1993-02-03 | — | — | EP | disclosed |