Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | NEK2 | P51955 | 2/20 | 0.43 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.43 |
| ▸ | MTHFD1 | P11586 | 1/20 | 0.42 |
| ▸ | MTHFD2 | P13995 | 1/20 | 0.42 |
| ▸ | SCN1A | P35498 | 2/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.42 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | CCR3 | P51677 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29900960 | 0.87 | MAOB (0.46) | MAOBMEN1KMT2AHRH1CCR3 | |
| SCHEMBL3513800 | 0.84 | GPR119 (0.42) | MAOAMAOBSMN1; SMN2HRH3BRD4 | |
| SCHEMBL1645653 | 0.81 | HRH3 (0.54) | MAOAMAOBSMN1; SMN2HRH3BRD4 | |
| SCHEMBL3641397 | 0.80 | LMNA (0.44) | MAOAMAOBSMN1; SMN2HRH3BRD4 | |
| Hydrochloric Acid SCHEMBL590423 | 0.79 | SMN1; SMN2 (0.44) | MAOAMAOBSMN1; SMN2HRH3MTHFD1 | |
| SCHEMBL20043816 | 0.79 | HRH3 (0.51) | MAOAMAOBSMN1; SMN2HRH3BRD4 | |
| SCHEMBL3510502 | 0.78 | CHEK2 (0.41) | CHEK2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL3644076 | 0.78 | CHEK2 (0.41) | CHEK2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL25725413 | 0.77 | HRH3 (0.50) | MAOAMAOBSMN1; SMN2HRH3BRD4 | |
| SCHEMBL3458790 | 0.77 | SRD5A1 (0.59) | SMN1; SMN2HRH3CHEK2MTHFD1MTHFD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176231-A1 | SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2010-04-21 | — | — | EP | disclosed |
| WO-2009013126-A1 | SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-01-29 | — | — | WO | disclosed |