SCHEMBL29900960

SCHEMBL29900960

Nc1cc(OC2CC2)ccc1C(=O)O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 1/20 0.46
ALDH1A1 P00352 5/20 0.44
KDM4E B2RXH2 2/20 0.44
HPGD P15428 1/20 0.44
HSD17B10 Q99714 1/20 0.44
IDO1 P14902 1/20 0.43
TDP1 Q9NUW8 3/20 0.42
CYP3A4 P08684 2/20 0.42
PARP10 Q53GL7 1/20 0.42
ALOX15 P16050 1/20 0.42
PPM1B O75688 1/20 0.41
MAPT P10636 3/20 0.41
MEN1 O00255 1/20 0.41
USP2 O75604 1/20 0.41
POLB P06746 1/20 0.41
THRB P10828 1/20 0.41
PKM P14618 1/20 0.41
APEX1 P27695 1/20 0.41
RECQL P46063 1/20 0.41
BLM P54132 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3645220 0.87 MAOA (0.46) MAOBKDM4EMEN1KMT2AHRH1
SCHEMBL30062254 0.84 ALDH1A1 (0.53) MAOBALDH1A1TDP1PARP10POLB
SCHEMBL22749358 0.83 ALDH1A1 (0.55) ALDH1A1KDM4EHPGDHSD17B10PARP10
SCHEMBL18114451 0.80 MAOB (0.46) MAOBALDH1A1TDP1PARP10EPHX2
SCHEMBL21434667 0.80 HRH1 (0.50) MAOBPARP10PTGS1PTGS2HRH1
SCHEMBL26124962 0.80 MAOB (0.46) MAOBALDH1A1HSD17B10TDP1PARP10
SCHEMBL714478 0.78 NR4A1 (0.52) ALDH1A1KDM4EHPGDHSD17B10IDO1
SCHEMBL29956935 0.78 MAOB (0.44) MAOBALDH1A1TDP1PARP10EPHX2
SCHEMBL28481347 0.77 MAOB (0.59) MAOBALDH1A1KDM4EHSD17B10PARP10
SCHEMBL27248979 0.77 PARP10 (0.50) MAOBTDP1PARP10MAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022187520-A1 SUBSTITUTED 3-PIPERIDINYL-PYRAZOLO[3,4-B]PYRIDINES AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS Ikena Oncology, Inc. (US) 2022-09-09 WO disclosed