Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.39 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3647018 | 0.93 | MEN1 (0.48) | MEN1KMT2AHPGDBCHEACHE | |
| SCHEMBL3648828 | 0.90 | LMNA (0.51) | MEN1KMT2AHPGDBCHEACHE | |
| SCHEMBL3653797 | 0.89 | RAB9A (0.45) | MEN1KMT2AHPGDSSTR1SSTR4 | |
| SCHEMBL3650434 | 0.87 | KMT2A (0.41) | MEN1KMT2AALDH1A1LMNANPC1 | |
| SCHEMBL3649973 | 0.86 | MEN1 (0.41) | MEN1KMT2AHPGDNPC1RAB9A | |
| SCHEMBL3648320 | 0.85 | MEN1 (0.51) | MEN1KMT2AHPGDALDH1A1LMNA | |
| SCHEMBL3651333 | 0.85 | NPC1 (0.42) | SSTR4ALDH1A1LMNANPC1RAB9A | |
| SCHEMBL3650513 | 0.84 | LMNA (0.48) | MEN1KMT2AHPGDL3MBTL1ALDH1A1 | |
| SCHEMBL3649551 | 0.84 | BCHE (0.43) | MEN1KMT2AHPGDBCHEACHE | |
| SCHEMBL3648571 | 0.84 | HPGD (0.48) | KMT2AHPGDL3MBTL1ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188263-A1 | BENZIMIDAZOLE DERIVATIVES USED AS FXR AGONISTS | F. Hoffmann-Roche AG (CH) | 2010-05-26 | — | — | EP | claimed |
| WO-2009027264-A1 | BENZIMIDAZOLE DERIVATIVES USED AS FXR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-03-05 | — | — | WO | claimed |
| EP-2188263-A1 | BENZIMIDAZOLE DERIVATIVES USED AS FXR AGONISTS | F. Hoffmann-Roche AG (CH) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009027264-A1 | BENZIMIDAZOLE DERIVATIVES USED AS FXR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-03-05 | — | — | WO | disclosed |