Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.53 |
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.40 |
| ▸ | TDP2 | O95551 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10604425 | 0.87 | ADRB2 (0.52) | ADRB2CTSLLMNACTSKFAAH | |
| SCHEMBL10604416 | 0.85 | ADRB2 (0.51) | ADRB2CTSLLMNACTSK | |
| SCHEMBL10607231 | 0.84 | NAAA (0.52) | ADRB2CTSLCTSK | |
| SCHEMBL10604253 | 0.83 | ADRB2 (0.55) | ADRB2CTSLLMNACTSKFAAH | |
| SCHEMBL10607221 | 0.80 | ADRB2 (0.57) | ADRB2CTSLLMNACTSKFAAH | |
| SCHEMBL1186102 | 0.80 | ADRB2 (0.57) | ADRB2CTSLLMNACTSKFAAH | |
| SCHEMBL27794391 | 0.79 | ADRB2 (0.60) | ADRB2CTSLLMNACTSKFAAH | |
| SCHEMBL10610238 | 0.78 | ADRB2 (0.76) | ADRB2CTSLLMNACTSKFAAH | |
| SCHEMBL1185448 | 0.77 | ADRB2 (0.55) | ADRB2CTSLLMNACTSKFAAH | |
| SCHEMBL1187444 | 0.77 | ADRB2 (0.55) | ADRB2CTSLLMNACTSKFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2203459-A1 | SPIROCYCLIC AMINOQUINOLONES AS GSK-3 INHIBITORS | Activx Biosciences, Inc. (US) | 2010-07-07 | — | — | EP | disclosed |
| WO-2009035684-A1 | SPIROCYCLIC AMINOQUINOLONES AS GSK-3 INHIBITORS | ACTIVX BIOSCIENCES, INC. (US) | 2009-03-19 | — | — | WO | disclosed |