Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 3/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 12/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3638644 | 0.86 | GHSR (0.50) | GHSRGPBAR1NR1H4SCN5ASCN9A | |
| SCHEMBL4332237 | 0.79 | GHSR (0.38) | GHSRGPBAR1NR1H4FFAR4SCN5A | |
| SCHEMBL3642990 | 0.78 | GHSR (0.48) | GHSRGPBAR1PTGS2 | |
| SCHEMBL1180837 | 0.75 | NR1H4 (0.53) | NR1H4 | |
| SCHEMBL4335252 | 0.74 | GHSR (0.50) | GHSRGPBAR1NR1H4SCN5ASCN9A | |
| SCHEMBL12168922 | 0.74 | GHSR (0.49) | GHSRGPBAR1NR1H4SCN5ASCN9A | |
| SCHEMBL3638890 | 0.72 | GHSR (0.48) | GHSRGPBAR1NR1H4SCN5ASCN9A | |
| SCHEMBL20859046 | 0.72 | NR1H4 (0.45) | NR1H4 | |
| SCHEMBL2004979 | 0.71 | NR1H4 (0.48) | NR1H4 | |
| SCHEMBL3637567 | 0.69 | GHSR (0.51) | GHSRGPBAR1NR1H4FFAR4SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173174-A1 | FARNESOID X RECEPTOR AGONISTS | GlaxoSmithKline LLC (US) | 2010-04-14 | — | — | EP | disclosed |
| EP-2079307-A2 | FARNESOID X RECEPTOR AGONISTS | SmithKline Beecham Corporation (US) | 2009-07-22 | — | — | EP | disclosed |
| WO-2009005998-A1 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-01-08 | — | — | WO | disclosed |
| WO-2008051942-A2 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-05-02 | — | — | WO | disclosed |