Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 5/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 8/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3638644 | 0.84 | GHSR (0.50) | GHSRNR1H4GPBAR1SCN5ASCN9A | |
| SCHEMBL3645682 | 0.79 | GHSR (0.38) | GHSRNR1H4FFAR4GPBAR1PTGS1 | |
| SCHEMBL2006971 | 0.78 | NR1H4 (0.55) | NR1H4 | |
| SCHEMBL4338523 | 0.77 | POLB (0.49) | GHSRNR1H4GPBAR1 | |
| SCHEMBL3638890 | 0.74 | GHSR (0.48) | GHSRNR1H4GPBAR1SCN5ASCN9A | |
| SCHEMBL4335252 | 0.73 | GHSR (0.50) | GHSRNR1H4GPBAR1SCN5ASCN9A | |
| SCHEMBL12168922 | 0.72 | GHSR (0.49) | GHSRNR1H4GPBAR1PTGS1SCN5A | |
| SCHEMBL3637567 | 0.68 | GHSR (0.51) | GHSRNR1H4FFAR4GPBAR1SCN5A | |
| SCHEMBL12168917 | 0.68 | GHSR (0.45) | GHSRNR1H4SCN5ASCN9APTGS2 | |
| SCHEMBL4953612 | 0.67 | GHSR (0.37) | GHSRNR1H4GPBAR1SCN5ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079307-A2 | FARNESOID X RECEPTOR AGONISTS | SmithKline Beecham Corporation (US) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008051942-A2 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-05-02 | — | — | WO | disclosed |