Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | PTGER2 | P43116 | 6/20 | 0.33 |
| ▸ | F2 | P00734 | 2/20 | 0.32 |
| ▸ | NAMPT | P43490 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.31 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.31 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.31 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | CLK1 | P49759 | 1/20 | 0.31 |
| ▸ | GLS | O94925 | 1/20 | 0.31 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3653190 | 0.91 | ABCC9 (0.33) | GPBAR1PTGER2F2NAMPTABCC9 | |
| SCHEMBL4126083 | 0.89 | GPBAR1 (0.36) | GPBAR1RXFP1PTGER2NAMPTPOLB | |
| SCHEMBL3648432 | 0.88 | GPBAR1 (0.39) | GPBAR1RXFP1PTGER2F2NAMPT | |
| SCHEMBL3654491 | 0.87 | NAMPT (0.35) | GPBAR1PTGER2F2NAMPTABCC9 | |
| SCHEMBL3645990 | 0.82 | PTGER2 (0.35) | GPBAR1RXFP1PTGER2NAMPTABCC9 | |
| SCHEMBL3649650 | 0.82 | NAMPT (0.36) | PTGER2F2NAMPTHTR2CSLC6A4 | |
| SCHEMBL3650554 | 0.80 | HTR2C (0.37) | GPBAR1RXFP1F2NAMPTHTR2C | |
| SCHEMBL4126584 | 0.79 | NAMPT (0.37) | GPBAR1PTGER2NAMPTABCC9ABCC8 | |
| Fumaric Acid SCHEMBL3650347 | 0.78 | TBXAS1 (0.36) | NAMPTPOLB | |
| Fumaric Acid SCHEMBL3650341 | 0.78 | TBXAS1 (0.36) | NAMPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2190822-A2 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009041705-A9 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2009-08-13 | — | — | WO | disclosed |
| WO-2009041705-A2 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-04-02 | — | — | WO | disclosed |