Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.45 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21411310 | 0.85 | GAA (0.45) | ALDH1A1SMN1; SMN2CYP1A2CYP2C9ALDH1A3 | |
| SCHEMBL17827635 | 0.81 | CHKA (0.44) | ALDH1A1NPC1MAPTRAB9AMETAP1 | |
| SCHEMBL5806811 | 0.81 | ADRA2C (0.45) | ALDH1A1MAPTKMT2ATDP1 | |
| SCHEMBL1801712 | 0.78 | SMN1; SMN2 (0.58) | ALDH1A1SMN1; SMN2CYP1A2CYP2C9ALDH3A1 | |
| SCHEMBL18412761 | 0.75 | POLB (0.51) | ALDH1A1SMN1; SMN2CYP1A2CYP2C9SCN9A | |
| SCHEMBL24342393 | 0.75 | CYP1A2 (0.45) | ALDH1A1SMN1; SMN2CYP1A2CYP2C9SCN9A | |
| SCHEMBL14878640 | 0.75 | ALOX15 (0.46) | ALDH1A1SMN1; SMN2CYP1A2CYP2C9SCN9A | |
| SCHEMBL2459669 | 0.75 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2CYP1A2CYP2C9SCN9A | |
| SCHEMBL823332 | 0.75 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2CYP1A2CYP2C9SCN9A | |
| SCHEMBL101958 | 0.74 | CYP1A2 (0.56) | ALDH1A1CYP1A2CYP2C9POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102675305-B | Imidazopyridine compounds, as well as preparation method and application thereof | SHANGHAI INST MATERIA MEDICA | 2014-11-12 | — | — | CN | disclosed |
| CN-103570683-A | Multi-substituted amine compound, as well as preparation method and use thereof | SHANGHAI INST MATERIA MEDICA | 2014-02-12 | — | — | CN | disclosed |
| CN-102675305-A | Imidazopyridine compounds, as well as preparation method and application thereof | SHANGHAI INST MATERIA MEDICA | 2012-09-19 | — | — | CN | disclosed |
| US-20100311748-A1 | HETEROCYCLIC AMIDES USEFUL FOR THE TREATMENT OF CANCER AND PSORIASIS | ASTRAZENECA AB (SE) | 2010-12-09 | — | — | US | disclosed |
| EP-2188255-A1 | HETEROCYCLIC AMIDES USEFUL FOR THE TREATMENT OF CANCER AND PSORIASIS | AstraZeneca AB (SE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009027746-A1 | HETEROCYCLIC AMIDES USEFUL FOR THE TREATMENT OF CANCER AND PSORIASIS | ASTRAZENECA AB (SE) | 2009-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100311748-A1 | HETEROCYCLIC AMIDES USEFUL FOR THE TREATMENT OF CANCER AND PSORIASIS | SHH, GLI1, HRH4 | ALDH1A1 1711/4885SMN1; SMN2 4749/4885CYP1A2 1878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.