Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 3/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CCR8 | P51685 | 1/20 | 0.42 |
| ▸ | MELK | Q14680 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3647473 | 0.93 | EGFR (0.44) | LTA4HEGFRBTKMELK | |
| SCHEMBL13472161 | 0.91 | LTA4H (0.45) | LTA4HALDH1A1KMT2AMAPTEGFR | |
| SCHEMBL3647130 | 0.90 | EGFR (0.45) | LTA4HKMT2AEGFRBTKMELK | |
| SCHEMBL13472144 | 0.90 | ALDH1A1 (0.50) | LTA4HALDH1A1KMT2AL3MBTL1HSD17B10 | |
| SCHEMBL3650235 | 0.89 | LTA4H (0.49) | LTA4HALDH1A1KMT2AL3MBTL1HSD17B10 | |
| SCHEMBL3644483 | 0.88 | LMNA (0.45) | LTA4HALDH1A1KMT2AL3MBTL1KDM4E | |
| SCHEMBL3651384 | 0.87 | EGFR (0.42) | LTA4HALDH1A1KMT2AL3MBTL1MAPT | |
| SCHEMBL3647131 | 0.82 | EGFR (0.41) | ALDH1A1EGFRBTK | |
| SCHEMBL3651441 | 0.81 | EGFR (0.46) | KMT2AEGFRBTKMELK | |
| SCHEMBL12846767 | 0.80 | EGFR (0.43) | LTA4HEGFRBTKMELKHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293757-B2 | 5-(4-(haloalkoxy)phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors | IRM LLC (BM) | 2012-10-23 | — | — | US | disclosed |
| EP-2190825-A1 | 5- (4- (HALOALKOXY) PHENYL) PYRIMIDINE-2-AMINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009026276-A1 | 5- (4- (HALOALKOXY) PHENYL) PYRIMIDINE-2-AMINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-02-26 | — | — | WO | disclosed |