Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3647326 | 0.82 | HPGD (0.44) | MTNR1AMTNR1BMAOBALDH1A1SMN1; SMN2 | |
| SCHEMBL3647331 | 0.82 | MAOB (0.59) | MTNR1AMTNR1BMAOBALDH1A1NPC1 | |
| SCHEMBL3645922 | 0.81 | MAOB (0.45) | MTNR1AMTNR1BMAOBALDH1A1NPC1 | |
| SCHEMBL3640648 | 0.80 | MAOB (0.48) | MAOBNPC1RAB9AMRGPRX1HCRTR1 | |
| SCHEMBL3647212 | 0.80 | MTNR1A (0.47) | MTNR1AMTNR1BMAOBALDH1A1NPC1 | |
| SCHEMBL3646928 | 0.80 | MTNR1A (0.50) | MTNR1AMTNR1BMAOBNPC1RAB9A | |
| SCHEMBL3645919 | 0.80 | MAOB (0.41) | MTNR1AMTNR1BMAOBMRGPRX1HCRTR1 | |
| SCHEMBL3645101 | 0.80 | LMNA (0.48) | MAOBNPC1RAB9ASMN1; SMN2MRGPRX1 | |
| SCHEMBL3641406 | 0.79 | MRGPRX1 (0.46) | MTNR1AMTNR1BMAOBMRGPRX1HCRTR1 | |
| SCHEMBL3641411 | 0.79 | MRGPRX1 (0.46) | ALDH1A1SMN1; SMN2MRGPRX1HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188282-A2 | 1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009022311-A2 | 1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2009-02-19 | — | — | WO | disclosed |