Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | BTK | Q06187 | 2/20 | 0.44 |
| ▸ | GFRA3 | O60609 | 5/20 | 0.39 |
| ▸ | RET | P07949 | 2/20 | 0.39 |
| ▸ | IDH2 | P48735 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 2/20 | 0.37 |
| ▸ | GFRA2 | O00451 | 3/20 | 0.36 |
| ▸ | GFRA1 | P56159 | 3/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | UBE2M | P61081 | 4/20 | 0.35 |
| ▸ | DCUN1D1 | Q96GG9 | 4/20 | 0.35 |
| ▸ | MELK | Q14680 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3652226 | 0.91 | EGFR (0.46) | EGFRBTKGFRA3RETIDH2 | |
| SCHEMBL3651384 | 0.91 | EGFR (0.42) | EGFRBTKPTK2 | |
| SCHEMBL3646358 | 0.91 | EGFR (0.43) | EGFRBTKGFRA3RETIDH2 | |
| SCHEMBL3651441 | 0.87 | EGFR (0.46) | EGFRBTKGFRA3RETMELK | |
| SCHEMBL3647130 | 0.85 | EGFR (0.45) | EGFRBTKGFRA3RETIDH2 | |
| SCHEMBL3644487 | 0.83 | EGFR (0.43) | EGFRBTKGFRA3RETIDH2 | |
| SCHEMBL5049010 | 0.81 | UBE2M (0.44) | PTK2UBE2MDCUN1D1 | |
| SCHEMBL3651931 | 0.81 | GRM5 (0.40) | EGFRBTKPTK2MELK | |
| SCHEMBL3646162 | 0.80 | EGFR (0.50) | EGFRBTK | |
| SCHEMBL3650240 | 0.80 | EGFR (0.47) | EGFRBTKGFRA3RETIDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2190825-A1 | 5- (4- (HALOALKOXY) PHENYL) PYRIMIDINE-2-AMINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-06-02 | — | — | EP | claimed |
| WO-2009026276-A1 | 5- (4- (HALOALKOXY) PHENYL) PYRIMIDINE-2-AMINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-02-26 | — | — | WO | claimed |
| US-8293757-B2 | 5-(4-(haloalkoxy)phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors | IRM LLC (BM) | 2012-10-23 | — | — | US | disclosed |
| EP-2190825-A1 | 5- (4- (HALOALKOXY) PHENYL) PYRIMIDINE-2-AMINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009026276-A1 | 5- (4- (HALOALKOXY) PHENYL) PYRIMIDINE-2-AMINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-02-26 | — | — | WO | disclosed |