Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.47 |
| ▸ | BTK | Q06187 | 3/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | GFRA3 | O60609 | 2/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | GALR2 | O43603 | 3/20 | 0.36 |
| ▸ | IDH2 | P48735 | 1/20 | 0.36 |
| ▸ | GALR1 | P47211 | 2/20 | 0.36 |
| ▸ | GFRA2 | O00451 | 1/20 | 0.36 |
| ▸ | GFRA1 | P56159 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3646162 | 0.86 | EGFR (0.50) | EGFRBTK | |
| SCHEMBL3651441 | 0.84 | EGFR (0.46) | EGFRBTKGFRA3RETKMT2A | |
| SCHEMBL3647130 | 0.83 | EGFR (0.45) | EGFRBTKGFRA3RETIDH2 | |
| SCHEMBL3646358 | 0.82 | EGFR (0.43) | EGFRBTKROCK2GFRA3RET | |
| SCHEMBL3650367 | 0.81 | EGFR (0.39) | EGFRBTKGSK3B | |
| SCHEMBL27807596 | 0.80 | GRM5 (0.39) | EGFRBTK | |
| SCHEMBL3647478 | 0.80 | EGFR (0.44) | EGFRBTKROCK2GFRA3RET | |
| SCHEMBL3650935 | 0.80 | ACHE (0.40) | EGFRBTK | |
| SCHEMBL3650235 | 0.80 | LTA4H (0.49) | EGFRBTKKMT2A | |
| SCHEMBL12442985 | 0.79 | L3MBTL1 (0.42) | EGFRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2190825-A1 | 5- (4- (HALOALKOXY) PHENYL) PYRIMIDINE-2-AMINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009026276-A1 | 5- (4- (HALOALKOXY) PHENYL) PYRIMIDINE-2-AMINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-02-26 | — | — | WO | disclosed |