Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3648464 | 1.00 | NPSR1 (0.34) | NPSR1MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL3646859 | 0.97 | NPSR1 (0.34) | NPSR1MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL3646858 | 0.97 | NPSR1 (0.34) | NPSR1MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL3646508 | 0.88 | ADRB2 (0.34) | NPSR1MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL3646505 | 0.88 | ADRB2 (0.34) | NPSR1MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL3648770 | 0.84 | MEN1 (0.32) | NPSR1MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL8471702 | 0.82 | ALDH1A1 (0.36) | NPSR1MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL8471703 | 0.82 | ALDH1A1 (0.36) | NPSR1MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL10551891 | 0.81 | KMT2A (0.37) | NPSR1MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL4567521 | 0.81 | MEN1 (0.40) | NPSR1MEN1KMT2ALMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2203459-A1 | SPIROCYCLIC AMINOQUINOLONES AS GSK-3 INHIBITORS | Activx Biosciences, Inc. (US) | 2010-07-07 | — | — | EP | disclosed |
| WO-2009035684-A1 | SPIROCYCLIC AMINOQUINOLONES AS GSK-3 INHIBITORS | ACTIVX BIOSCIENCES, INC. (US) | 2009-03-19 | — | — | WO | disclosed |