Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 5/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8471703 | 1.00 | ALDH1A1 (0.36) | ALDH1A1KDM4ENPC1KMT2AMAPT | |
| SCHEMBL3646508 | 0.86 | ADRB2 (0.34) | ALDH1A1KDM4ENPC1KMT2AMAPT | |
| SCHEMBL3646505 | 0.86 | ADRB2 (0.34) | ALDH1A1KDM4ENPC1KMT2AMAPT | |
| SCHEMBL3646858 | 0.86 | NPSR1 (0.34) | ALDH1A1KDM4ENPC1KMT2AMAPT | |
| SCHEMBL3646859 | 0.86 | NPSR1 (0.34) | ALDH1A1KDM4ENPC1KMT2AMAPT | |
| SCHEMBL3648770 | 0.84 | MEN1 (0.32) | KMT2AMAPTMEN1NPSR1LMNA | |
| SCHEMBL3648468 | 0.82 | NPSR1 (0.34) | KDM4EKMT2AMAPTMEN1NPSR1 | |
| SCHEMBL3648464 | 0.82 | NPSR1 (0.34) | KDM4EKMT2AMAPTMEN1NPSR1 | |
| SCHEMBL3651199 | 0.82 | MEN1 (0.32) | KMT2AMAPTMEN1NPSR1LMNA | |
| SCHEMBL9561731 | 0.81 | MEN1 (0.40) | KMT2AMAPTMEN1NPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5892040-A | Process for the manufacture of a tricyclic compound | PFIZER. INC (US) | 1999-04-06 | — | — | US | disclosed |
| EP-0680482-B1 | PROCESS FOR THE MANUFACTURE OF A TRICYCLIC COMPOUND | PFIZER (US) | 1997-04-02 | — | — | EP | disclosed |
| EP-0680482-A1 | PROCESS FOR THE MANUFACTURE OF A TRICYCLIC COMPOUND. | PFIZER (US) | 1995-11-08 | — | — | EP | disclosed |
| WO-1994017074-A1 | PROCESS FOR THE MANUFACTURE OF A TRICYCLIC COMPOUND | PFIZER INC. (US) | 1994-08-04 | — | — | WO | disclosed |