Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 12/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 12/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2890768 | 0.84 | MT-CO2 (0.41) | POLBPTPN11ATRCYP4F2CYP4A11 | |
| SCHEMBL3655649 | 0.80 | RAB9A (0.36) | ALOX15 | |
| SCHEMBL3647691 | 0.80 | CNR1 (0.41) | — | |
| SCHEMBL3646652 | 0.79 | KDM4E (0.42) | POLB | |
| SCHEMBL3653802 | 0.76 | MAP4K4 (0.36) | ALOX15 | |
| SCHEMBL3651665 | 0.75 | CYP1A2 (0.42) | — | |
| SCHEMBL3655990 | 0.75 | RAB9A (0.42) | — | |
| SCHEMBL3649322 | 0.71 | CNR1 (0.47) | — | |
| SCHEMBL3650950 | 0.71 | SCN2A (0.36) | POLB | |
| SCHEMBL13028188 | 0.69 | KDR (0.48) | POLBPTPN11PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2203436-A1 | PYRAZINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-07-07 | — | — | EP | disclosed |
| WO-2009037247-A1 | PYRAZINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2009-03-26 | — | — | WO | disclosed |