Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15880895 | 0.89 | NPSR1 (0.41) | HCAR2GRM5RXRAGAAKMT2A | |
| SCHEMBL4414506 | 0.82 | MT-CO2 (0.33) | MAP4K4S1PR3GRM5RXRAGAA | |
| SCHEMBL3655649 | 0.80 | RAB9A (0.36) | MAP4K4CNR1GAAMEN1KMT2A | |
| SCHEMBL3646652 | 0.79 | KDM4E (0.42) | CNR1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL2890838 | 0.79 | MT-CO2 (0.49) | S1PR3RXRACNR1GAAMEN1 | |
| SCHEMBL3647691 | 0.77 | CNR1 (0.41) | GRM5CNR1MEN1KMT2ARAB9A | |
| SCHEMBL3655990 | 0.77 | RAB9A (0.42) | GRM5CNR1GAAMEN1KMT2A | |
| SCHEMBL3649237 | 0.76 | POLB (0.39) | ALOX15 | |
| SCHEMBL3651665 | 0.76 | CYP1A2 (0.42) | MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL21258985 | 0.74 | ALDH1A1 (0.44) | GRM5CNR1GAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2203436-A1 | PYRAZINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-07-07 | — | — | EP | disclosed |
| WO-2009037247-A1 | PYRAZINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2009-03-26 | — | — | WO | disclosed |