SCHEMBL3650040

SCHEMBL3650040

Cc1oncc1OC(=O)O

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.35
CSF1R P07333 1/20 0.35
ALDH1A1 P00352 1/20 0.33
HSD17B10 Q99714 1/20 0.33
RAB9A P51151 3/20 0.33
NPC1 O15118 2/20 0.33
GMNN O75496 1/20 0.33
TP53 P04637 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
HTR1A P08908 1/20 0.33
THRB P10828 1/20 0.33
PIM1 P11309 1/20 0.33
CYP2C9 P11712 1/20 0.33
MAOA P21397 1/20 0.33
SLC6A2 P23975 1/20 0.33
HTR2A P28223 1/20 0.33
AGTR1 P30556 1/20 0.33
CCKBR P32239 1/20 0.33
MC4R P32245 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3878932 0.82 LMNA (0.34) LMNACSF1RRAB9ANPC1GMNN
SCHEMBL8439007 0.78
SCHEMBL11435438 0.72 NPC1 (0.31) LMNARAB9ANPC1GMNNTP53
SCHEMBL10403923 0.72
SCHEMBL6931877 0.70 THRB (0.48) LMNARAB9ANPC1GMNNTP53
SCHEMBL439222 0.68
SCHEMBL6142432 0.67 MAPT (0.41) LMNAALDH1A1RAB9ANPC1CYP3A4
Hydrochloric Acid SCHEMBL5593733 0.67 LMNA (0.51) LMNACSF1RALDH1A1HSD17B10RAB9A
SCHEMBL29261172 0.67 LMNA (0.51) LMNACSF1RALDH1A1HSD17B10RAB9A
SCHEMBL27969576 0.66 LMNA (0.50) LMNACSF1RALDH1A1HSD17B10RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3310755-B1 A NOVEL PROCESS FOR THE PREPARATION OF TERIFLUNOMIDE BIOCON LTD (IN) 2021-02-24 EP claimed
EP-1377589-B1 OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS PHARMACIA ITALIA SPA (IT) 2005-09-07 EP claimed
EP-1257270-B1 A METHOD FOR SYNTHESIZING LEFLUNOMIDE TEVA PHARMA (IL) 2005-04-13 EP claimed
EP-2086993-B1 MICHAEL SYSTEMS AS TRANSGLUTAMINASE INHIBITORS ZEDIRA GMBH (DE) 2015-03-11 EP disclosed
EP-2188254-A1 NOVEL BRADYKININ B1-ANTAGONISTS Boehringer Ingelheim International GmbH (DE) 2010-05-26 EP disclosed
EP-2086993-A1 MICHAEL SYSTEMS AS TRANSGLUTAMINASE INHIBITORS Zedira GmbH (DE) 2009-08-12 EP disclosed
WO-2009027450-A1 NOVEL BRADYKININ B1-ANTAGONISTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2009-03-05 WO disclosed
EP-2010507-A2 NOVEL ISOOXAZOLE DERIVATIVES AND THEIR USES ScheBo Biotech Aktiengesellschaft (DE) 2009-01-07 EP disclosed
WO-2008055488-A1 MICHAEL SYSTEMS AS TRANSGLUTAMINASE INHIBITORS ZEDIRA GMBH (DE) 2008-05-15 WO disclosed
WO-2007110068-A2 NOVEL ISOOXAZOLE DERIVATIVES AND THEIR USES SCHEBO BIOTECH AG (DE) 2007-10-04 WO disclosed
EP-1499612-A1 PIPERIDINE OURACIL USED AS A MEDICAMENT FOR TREATING BACTERIAL INFECTIONS Bayer HealthCare AG (DE) 2005-01-26 EP disclosed
WO-2003072574-A1 PIPERIDINE OURACIL USED AS A MEDICAMENT FOR TREATING BACTERIAL INFECTIONS BAYER HEALTHCARE AG (DE) 2003-09-04 WO disclosed
EP-0859000-B1 Isoxazole amide and crotonamid derivatives and drug and diagnostic uses thereof AVENTIS PHARMA GMBH (DE) 2003-01-22 EP disclosed
EP-0859000-A1 Isoxazole amide and crotonamid derivatives and drug and diagnostic uses thereof HOECHST AKTIENGESELLSCHAFT (DE) 1998-08-19 EP disclosed
EP-0527736-A1 ISOXAZOLE-4-CARBOXAMIDES AND HYDROXYALKYLIDENE-CYANOACETAMIDES, DRUGS CONTAINING THESE COMPOUNDS AND USE OF SUCH DRUGS. HOECHST AG (DE) 1993-02-24 EP disclosed
WO-1991017748-A1 ISOXAZOLE-4-CARBOXAMIDES AND HYDROXYALKYLIDENE-CYANOACETAMIDES, DRUGS CONTAINING THESE COMPOUNDS AND USE OF SUCH DRUGS HOECHST AKTIENGESELLSCHAFT (DE) 1991-11-28 WO disclosed
EP-0013376-B1 ISOXAZOLE DERIVATIVE, PROCESS FOR ITS PREPARATION AND COMPOSITION CONTAINING IT HOECHST AKTIENGESELLSCHAFT (DE) 1982-05-19 EP disclosed
EP-0013376-A2 Isoxazole derivative, process for its preparation and composition containing it HOECHST AKTIENGESELLSCHAFT (DE) 1980-07-23 EP disclosed