Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 7/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2314054 | 0.92 | THRB (0.70) | THRBHPGDHTTTP53SMN1; SMN2 | |
| SCHEMBL2319467 | 0.87 | HPGD (0.64) | THRBHPGDHTTTP53SMN1; SMN2 | |
| SCHEMBL27807378 | 0.79 | HPGD (0.76) | THRBHPGDHTTTP53MEN1 | |
| SCHEMBL2419952 | 0.78 | THRB (0.74) | THRBHPGDHTTTP53SMN1; SMN2 | |
| SCHEMBL10321762 | 0.77 | HPGD (0.62) | THRBHPGDHTTTP53SMN1; SMN2 | |
| SCHEMBL10322196 | 0.77 | KDM4E (0.60) | THRBHPGDHTTSMN1; SMN2MEN1 | |
| SCHEMBL5551614 | 0.73 | HPGD (0.74) | THRBHPGDHTTSMN1; SMN2MEN1 | |
| SCHEMBL10634286 | 0.73 | MEN1 (0.67) | HPGDSMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL31396768 | 0.72 | HPGD (0.68) | THRBHPGDHTTTP53SMN1; SMN2 | |
| SCHEMBL8302813 | 0.72 | SMN1; SMN2 (0.60) | HPGDHTTSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183222-A2 | AZOLORAINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICALS CONTAINING THESE COMPOUNDS, AND THE USE THEREOF | Sanofi-Aventis (FR) | 2010-05-12 | — | — | EP | disclosed |
| WO-2009024287-A2 | AZOLORAINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICALS CONTAINING THESE COMPOUNDS, AND THE USE THEREOF | SANOFI-AVENTIS (FR) | 2009-02-26 | — | — | WO | disclosed |