Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | CASP6 | P55212 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10318606 | 0.88 | ALDH1A1 (0.71) | SMN1; SMN2NPC1RAB9AL3MBTL1HPGD | |
| SCHEMBL10768291 | 0.88 | L3MBTL1 (0.77) | SMN1; SMN2NPC1RAB9AL3MBTL1HPGD | |
| SCHEMBL1455766 | 0.88 | SMN1; SMN2 (0.77) | SMN1; SMN2HPGDCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL27214426 | 0.83 | POLB (0.56) | SMN1; SMN2NPC1RAB9AL3MBTL1HPGD | |
| SCHEMBL8848390 | 0.82 | MEN1 (0.55) | SMN1; SMN2RAB9AL3MBTL1HPGDCYP1A2 | |
| SCHEMBL17131801 | 0.81 | ALDH1A1 (0.80) | SMN1; SMN2L3MBTL1HPGDLMNAKMT2A | |
| SCHEMBL606248 | 0.81 | ALDH1A1 (0.80) | SMN1; SMN2NPC1RAB9AL3MBTL1HPGD | |
| SCHEMBL8651240 | 0.81 | ALDH1A1 (0.69) | SMN1; SMN2NPC1RAB9AL3MBTL1CYP1A2 | |
| SCHEMBL15609584 | 0.81 | RAB9A (0.65) | SMN1; SMN2NPC1RAB9AL3MBTL1HPGD | |
| SCHEMBL11615300 | 0.81 | RAB9A (0.74) | SMN1; SMN2NPC1RAB9AHPGDCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934068-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998009630-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-03-12 | — | — | WO | disclosed |