Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 7/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | GPR68 | Q15743 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3650131 | 0.84 | PRKCI (0.50) | PRKCIFYNCDK8CHRNB4CHRNA3 | |
| SCHEMBL13285567 | 0.84 | PRKCI (0.50) | PRKCIFYNCDK8CNR2CHRNB4 | |
| SCHEMBL1301002 | 0.84 | PRKCI (0.50) | PRKCIFYNCDK8CNR2ACMSD | |
| SCHEMBL31500185 | 0.84 | PRKCI (0.50) | PRKCIFYNCDK8CHRNB4CHRNA3 | |
| SCHEMBL1581550 | 0.84 | PRKCI (0.50) | PRKCIFYNCDK8CHRNB4CHRNA3 | |
| SCHEMBL2130914 | 0.83 | PRKCI (0.61) | PRKCIFYNCDK8CNR2ACMSD | |
| SCHEMBL2540857 | 0.81 | ACMSD (0.51) | PRKCIFYNCDK8CNR2ACMSD | |
| SCHEMBL22310395 | 0.80 | FYN (0.51) | PRKCIFYNCDK8S1PR1S1PR3 | |
| SCHEMBL22309842 | 0.79 | S1PR1 (0.52) | PRKCIFYNCDK8S1PR1S1PR3 | |
| SCHEMBL27813877 | 0.79 | PRKCI (0.51) | PRKCIFYNCDK8CNR2ACMSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2181111-B1 | THIADIAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-06-26 | — | — | EP | disclosed |
| CN-101784544-B | Thiadiazinone derivatives | MERCK PATENT GMBH | 2012-08-29 | — | — | CN | disclosed |
| US-8211886-B2 | Thiadiazinone derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-07-03 | — | — | US | disclosed |
| US-20100311733-A1 | THIADIAZINONE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT ESCHRANKTER HAFTUNG (DE) | 2010-12-09 | — | — | US | disclosed |
| CN-101784544-A | thiadiazinone derivatives | MERCK PATENT GMBH | 2010-07-21 | — | — | CN | disclosed |
| EP-2181111-A1 | THIADIAZINONE DERIVATIVES | Merck Patent GmbH (DE) | 2010-05-05 | — | — | EP | disclosed |
| WO-2009030333-A1 | THIADIAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2009-03-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100311733-A1 | THIADIAZINONE DERIVATIVES | MET, ABL1, RET | PRKCI 749/4885FYN 342/4885CDK8 311/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.