Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Benzamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.94 |
| ▸ | TSHR | P16473 | 2/20 | 0.94 |
| ▸ | POLB | P06746 | 1/20 | 0.94 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.94 |
| ▸ | MAPT | P10636 | 1/20 | 0.94 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.94 |
| ▸ | RECQL | P46063 | 1/20 | 0.94 |
| ▸ | BLM | P54132 | 1/20 | 0.94 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.94 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.94 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.94 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.94 |
| ▸ | PARP10 | Q53GL7 | 5/20 | 0.60 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.60 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.60 |
| ▸ | CES2 | O00748 | 2/20 | 0.55 |
| ▸ | CES1 | P23141 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | DAO | P14920 | 1/20 | 0.55 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzamide SCHEMBL10182095 | 1.00 | PARP1 (0.94) | PARP1TSHRPOLBCYP3A4MAPT | |
| Benzamide SCHEMBL27963599 | 0.97 | PARP1 (1.00) | PARP1TSHRPOLBCYP3A4MAPT | |
| SCHEMBL21755166 | 0.97 | PARP1 (1.00) | PARP1TSHRPOLBCYP3A4MAPT | |
| Benzamide SCHEMBL1332331 | 0.97 | — | — | |
| Benzamide SCHEMBL16352 | 0.97 | — | — | |
| Benzamide SCHEMBL30112947 | 0.97 | PARP1 (1.00) | PARP1TSHRPOLBCYP3A4MAPT | |
| Benzamide SCHEMBL29618402 | 0.97 | — | — | |
| Benzamide SCHEMBL1222101 | 0.97 | PARP1 (1.00) | PARP1TSHRPOLBCYP3A4MAPT | |
| Benzamide SCHEMBL6690447 | 0.97 | PARP1 (1.00) | PARP1TSHRPOLBCYP3A4MAPT | |
| Benzamide SCHEMBL11668921 | 0.97 | PARP1 (1.00) | PARP1TSHRPOLBCYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118843457-A | Dual LSD1/HDAC inhibitors | 朱比连特埃皮科尔有限责任公司 | 2024-10-25 | — | — | CN | claimed |
| CN-116234331-A | Perovskite solar cell based on benzamide bromine modification and preparation method thereof | 太原理工大学 | 2023-06-06 | — | — | CN | claimed |
| CN-113135816-A | Method for synthesizing photoactive bromohydrin compound | 常州大学 | 2021-07-20 | — | — | CN | claimed |
| CN-116234331-B | Perovskite solar cell based on benzamide bromine modification and preparation method thereof | TAIYUAN UNIVERSITY OF TECHNOLOGY (CN) | 2026-05-29 | — | — | CN | disclosed |
| CN-116234331-B | Perovskite solar cell based on benzamide bromine modification and preparation method thereof | TAIYUAN UNIVERSITY OF TECHNOLOGY (CN) | 2026-05-29 | — | — | CN | disclosed |
| CN-118843457-A | Dual LSD1/HDAC inhibitors | 朱比连特埃皮科尔有限责任公司 | 2024-10-25 | — | — | CN | disclosed |
| US-20230323200-A1 | MACROMOLECULAR AMMONIUM AND GUANIDINIUM HALIDES FOR TUNING COLOR OF PEROVSKITE NANOCRYSTALS | NATIONAL SCIENCE FOUNDATION | 2023-10-12 | — | — | US | disclosed |
| CN-116234331-A | Perovskite solar cell based on benzamide bromine modification and preparation method thereof | 太原理工大学 | 2023-06-06 | — | — | CN | disclosed |
| CN-116234331-A | Perovskite solar cell based on benzamide bromine modification and preparation method thereof | 太原理工大学 | 2023-06-06 | — | — | CN | disclosed |
| CN-116234331-A | Perovskite solar cell based on benzamide bromine modification and preparation method thereof | 太原理工大学 | 2023-06-06 | — | — | CN | disclosed |
| CN-115662691-A | Sectional type moisture-proof cable and preparation method thereof | 刘启铃 | 2023-01-31 | — | — | CN | disclosed |
| CN-103461369-A | Insect disinfestation composition containing bromoantraniliprole and neonicotine | SHAANXI MEIBANG PESTICIDES CO | 2013-12-25 | — | — | CN | disclosed |
| EP-2207773-A2 | HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF | Otsuka Pharmaceutical Co., Ltd. (JP) | 2010-07-21 | — | — | EP | disclosed |
| CN-100536036-C | Method for producing electrolyte membrane and membrane electrode assembly, and fuel cell | TOAGOSEI CO LTD (JP) | 2009-09-02 | — | — | CN | disclosed |
| WO-2009057811-A2 | HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2009-05-07 | — | — | WO | disclosed |
| CN-1942980-A | Method for producing electrolyte membrane and membrane electrode assembly, and fuel cell | TOAGOSEI CO LTD (JP) | 2007-04-04 | — | — | CN | disclosed |
| EP-1343751-A2 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-09-17 | — | — | EP | disclosed |
| WO-2002060859-A2 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-08-08 | — | — | WO | disclosed |
| CN-1023700-C | Aromatic and heterocyclic carboxamide derivatives as antineoplastic agents | PFIZER (US) | 1994-02-09 | — | — | CN | disclosed |
| CN-1037898-A | The preparation of aromatics and Heterocyclylcarboxamderivatives derivatives antineoplastic agent | PFIZER (US) | 1989-12-13 | — | — | CN | disclosed |