Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GBA1 | P04062 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3116696 | 0.93 | KMT2A (0.56) | LMNAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL3019227 | 0.89 | KMT2A (0.54) | LMNAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL3008167 | 0.86 | KMT2A (0.58) | LMNAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL3649359 | 0.85 | SMN1; SMN2 (0.55) | LMNAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL3651711 | 0.84 | ALDH1A1 (0.53) | LMNAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL3016409 | 0.84 | KMT2A (0.61) | LMNAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL3650332 | 0.83 | ALDH1A1 (0.52) | LMNAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL3653902 | 0.82 | HSD11B1 (0.45) | LMNAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL3016559 | 0.82 | KMT2A (0.52) | LMNAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL3007681 | 0.82 | LMNA (0.63) | LMNAMEN1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188272-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV Remynd (BE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009019295-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-02-12 | — | — | WO | disclosed |