Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.34 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3003595 | 0.94 | ALDH1A1 (0.38) | LPAR1LPAR2ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL3016879 | 0.93 | HCRTR1 (0.40) | HCRTR1HCRTR2LPAR1LPAR2ALDH1A1 | |
| SCHEMBL3017827 | 0.89 | ALDH1A1 (0.38) | LPAR1LPAR2ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL3016072 | 0.87 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2L3MBTL1MAPTMEN1 | |
| SCHEMBL3014308 | 0.87 | ABL1 (0.38) | LPAR1LPAR2MEN1LMNAKMT2A | |
| SCHEMBL3016917 | 0.87 | TRPV4 (0.37) | LPAR1LPAR2ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL3016449 | 0.86 | LMNA (0.37) | ALDH1A1SMN1; SMN2L3MBTL1MAPTMEN1 | |
| SCHEMBL3015598 | 0.86 | TRPV4 (0.44) | LPAR1LPAR2ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL3652946 | 0.86 | CNR1 (0.42) | ALDH1A1SMN1; SMN2L3MBTL1MAPTCNR1 | |
| SCHEMBL3651870 | 0.86 | ALDH1A1 (0.37) | LPAR1LPAR2ALDH1A1SMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188272-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV Remynd (BE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009019295-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-02-12 | — | — | WO | disclosed |