SCHEMBL3654236

SCHEMBL3654236

COc1ccc(C(CO)C(c2ccnc(-c3ccc(C(=O)O)cc3)c2)C(F)(F)F)c(Cl)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LOXL2 Q9Y4K0 1/20 0.37
CHEK1 O14757 1/20 0.37
MRGPRX4 Q96LA9 1/20 0.37
CYP2C8 P10632 1/20 0.36
MAP4K4 O95819 1/20 0.36
HDAC1 Q13547 4/20 0.36
KDM1A O60341 3/20 0.36
HDAC6 Q9UBN7 3/20 0.36
HDAC2 Q92769 2/20 0.35
HDAC8 Q9BY41 2/20 0.35
HDAC5 Q9UQL6 2/20 0.35
KMO O15229 1/20 0.35
KDM5A P29375 1/20 0.35
KDM2B Q8NHM5 1/20 0.35
KDM4C Q9H3R0 1/20 0.35
KDM5B Q9UGL1 1/20 0.35
KDM4E B2RXH2 2/20 0.35
ALDH1A1 P00352 2/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3658104 0.92 MRGPRX4 (0.42) MRGPRX4KMOKDM5AKDM2BKDM4C
SCHEMBL3656432 0.90 CDC7 (0.38) HDAC1KDM1AHDAC6NPC1RAB9A
SCHEMBL3658899 0.86 NR1H4 (0.37) MRGPRX4NPC1RAB9ASMN1; SMN2ABL1
SCHEMBL3661830 0.81 LOXL2 (0.43) LOXL2CHEK1MRGPRX4HDAC1KDM1A
SCHEMBL3656807 0.79 KMO (0.39) MRGPRX4MAP4K4KMOKDM5AKDM4C
SCHEMBL837203 0.76 CHEK1 (0.39) LOXL2CHEK1MRGPRX4CYP2C8MAP4K4
SCHEMBL3660214 0.73 MRGPRX4 (0.44) MRGPRX4KMOKDM5AKDM4CKDM5B
SCHEMBL3803786 0.71 MRGPRX4 (0.37) MRGPRX4KMOKDM5AKDM4CKDM5B
SCHEMBL3652326 0.71 CDC7 (0.39) HDAC1KDM1AHDAC6HDAC2HDAC8
SCHEMBL837915 0.69 MRGPRX4 (0.41) MRGPRX4CYP2C8KMOKDM5AKDM2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2205562-A1 1,1,1-TRIFLUORO-2-HYDROXY-3-PHENYLPROPANE DERIVATIVES F. Hoffmann-Roche AG (CH) 2010-07-14 EP claimed
WO-2009040288-A1 1,1,1-TRIFLUORO-2-HYDROXY-3-PHENYLPROPANE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2009-04-02 WO claimed
EP-2205562-A1 1,1,1-TRIFLUORO-2-HYDROXY-3-PHENYLPROPANE DERIVATIVES F. Hoffmann-Roche AG (CH) 2010-07-14 EP disclosed
WO-2009040288-A1 1,1,1-TRIFLUORO-2-HYDROXY-3-PHENYLPROPANE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2009-04-02 WO disclosed