Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.37 |
| ▸ | KDM1A | O60341 | 3/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3660214 | 0.92 | MRGPRX4 (0.44) | MRGPRX4KDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL3652326 | 0.90 | CDC7 (0.39) | HDAC1KDM1AHDAC6HDAC2HDAC8 | |
| SCHEMBL3654236 | 0.81 | LOXL2 (0.37) | LOXL2MRGPRX4HDAC1KDM1AHDAC6 | |
| SCHEMBL3651279 | 0.79 | KMO (0.39) | LOXL2MRGPRX4RORCKMOKDM5A | |
| SCHEMBL3657608 | 0.77 | EIF4E (0.36) | LOXL2KMOKDM4C | |
| SCHEMBL3659044 | 0.77 | MRGPRX4 (0.38) | MRGPRX4 | |
| SCHEMBL3659842 | 0.76 | KMO (0.36) | LOXL2MRGPRX4KMO | |
| SCHEMBL837203 | 0.76 | CHEK1 (0.39) | LOXL2MRGPRX4HDAC1KDM1AHDAC6 | |
| SCHEMBL3658104 | 0.73 | MRGPRX4 (0.42) | MRGPRX4KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL3653818 | 0.73 | CDC7 (0.38) | MRGPRX4KDM4EALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205562-A1 | 1,1,1-TRIFLUORO-2-HYDROXY-3-PHENYLPROPANE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009040288-A1 | 1,1,1-TRIFLUORO-2-HYDROXY-3-PHENYLPROPANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-02 | — | — | WO | disclosed |