Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | BCL9 | O00512 | 2/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | F11 | P03951 | 1/20 | 0.31 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3657524 | 0.92 | PARP10 (0.39) | PARP10BCL9CTNNB1FLT3KDM1A | |
| Trifluoroacetic Acid SCHEMBL3654252 | 0.87 | FLT3 (0.33) | FLT3 | |
| Trifluoroacetic Acid SCHEMBL3650183 | 0.85 | MAPK14 (0.33) | BCL9CTNNB1KDM1ACHEK2 | |
| SCHEMBL2636793 | 0.84 | BCL9 (0.33) | BCL9CTNNB1 | |
| Trifluoroacetic Acid SCHEMBL3654963 | 0.84 | — | — | |
| Trifluoroacetic Acid SCHEMBL3659571 | 0.83 | RAB9A (0.45) | — | |
| Trifluoroacetic Acid SCHEMBL3653624 | 0.82 | KDM4E (0.40) | — | |
| SCHEMBL3655820 | 0.80 | SLC6A2 (0.35) | FLT3 | |
| Trifluoroacetic Acid SCHEMBL3653109 | 0.80 | RAB9A (0.45) | — | |
| Trifluoroacetic Acid SCHEMBL3650317 | 0.79 | EPHX2 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2215058-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE UREAS AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2010-08-11 | — | — | EP | disclosed |
| EP-2212282-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009052065-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-04-23 | — | — | WO | disclosed |
| WO-2009052068-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE UREAS AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-04-23 | — | — | WO | disclosed |