Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.42 |
| ▸ | BAD | Q92934 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3654349 | 1.00 | HTR7 (0.44) | HTR7CES2CES1BCL2L1BAD | |
| SCHEMBL3654354 | 1.00 | HTR7 (0.44) | HTR7CES2CES1BCL2L1BAD | |
| SCHEMBL1982008 | 0.82 | CES2 (0.50) | CES2CES1ESR1SMN1; SMN2ESR2 | |
| SCHEMBL1982010 | 0.82 | CES2 (0.50) | CES2CES1ESR1SMN1; SMN2ESR2 | |
| SCHEMBL3864914 | 0.79 | ESR1 (0.64) | CES2ESR1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL3864922 | 0.79 | ESR1 (0.64) | CES2ESR1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL3864916 | 0.79 | ESR1 (0.64) | CES2ESR1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL4475097 | 0.76 | CES2 (0.50) | HTR7CES2CES1BCL2L1BAD | |
| SCHEMBL1695621 | 0.76 | ESR1 (0.53) | NPC1RAB9AESR1ALDH1A1KMT2A | |
| SCHEMBL1695617 | 0.75 | ESR1 (0.52) | ESR1ALDH1A1KMT2ASMN1; SMN2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8236987-B2 | Selective estrogen receptor modulator compositions and methods for treatment of disease | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-08-07 | — | — | US | disclosed |
| EP-2227450-A2 | SELECTIVE ESTROGEN RECEPTOR MODULATOR COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASE | Oregon Health&Science University (US) | 2010-09-15 | — | — | EP | disclosed |
| US-20090124698-A1 | SELECTIVE ESTROGEN RECEPTOR MODULATOR COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASE | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2009-05-14 | — | — | US | disclosed |
| WO-2009062082-A2 | SELECTIVE ESTROGEN RECEPTOR MODULATOR COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASE | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2009-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124698-A1 | SELECTIVE ESTROGEN RECEPTOR MODULATOR COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASE | ESR1, GPER1, ESR2 | HTR7 474/4885CES2 1405/4885CES1 455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.