Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | USP2 | O75604 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 6/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3003300 | 0.95 | MAPT (0.38) | MAPTUSP2RECQLHSD17B10ALDH1A1 | |
| SCHEMBL3015605 | 0.94 | SMN1; SMN2 (0.36) | MAPTUSP2RECQLHSD17B10ALDH1A1 | |
| SCHEMBL3018378 | 0.90 | LMNA (0.38) | MAPTUSP2RECQLHSD17B10ALDH1A1 | |
| SCHEMBL3017054 | 0.86 | MEN1 (0.38) | MAPTUSP2RECQLHSD17B10ALDH1A1 | |
| SCHEMBL3004059 | 0.84 | MAPT (0.37) | MAPTUSP2RECQLHSD17B10ALDH1A1 | |
| SCHEMBL3013890 | 0.84 | PKM (0.43) | MAPTUSP2RECQLHSD17B10ALDH1A1 | |
| SCHEMBL3017349 | 0.83 | ALDH1A1 (0.37) | MAPTUSP2RECQLHSD17B10ALDH1A1 | |
| SCHEMBL3014739 | 0.82 | F2RL3 (0.32) | SMN1; SMN2LMNAMEN1KMT2AMAPK1 | |
| SCHEMBL3007471 | 0.82 | SMN1; SMN2 (0.40) | MAPTUSP2RECQLHSD17B10ALDH1A1 | |
| SCHEMBL3016034 | 0.82 | PKM (0.45) | MAPTUSP2RECQLHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188272-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV Remynd (BE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009019295-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-02-12 | — | — | WO | disclosed |