Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.73 |
| ▸ | RAB9A | P51151 | 2/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.59 |
| ▸ | ACHE | P22303 | 1/20 | 0.59 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.58 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.58 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.58 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17117491 | 0.89 | MEN1 (0.84) | MEN1KMT2ARAB9AALDH1A1GAA | |
| SCHEMBL17117334 | 0.81 | KMT2A (0.85) | MEN1KMT2ARAB9AALDH1A1GAA | |
| SCHEMBL8691052 | 0.81 | MAPT (0.76) | RAB9AALDH1A1PTPN1GAAMAPT | |
| SCHEMBL3655081 | 0.79 | PTPN1 (0.67) | MEN1KMT2ARAB9AALDH1A1PTPN1 | |
| SCHEMBL11426452 | 0.79 | SMN1; SMN2 (0.57) | MEN1KMT2AALDH1A1PTPN1TAAR1 | |
| SCHEMBL12773610 | 0.78 | SMN1; SMN2 (0.75) | MEN1KMT2AALDH1A1PTPN1TAAR1 | |
| SCHEMBL14068428 | 0.77 | MEN1 (0.59) | MEN1KMT2ARAB9AALDH1A1GAA | |
| SCHEMBL6530877 | 0.77 | SMN1; SMN2 (0.69) | MEN1KMT2ARAB9AALDH1A1PTPN1 | |
| SCHEMBL13073723 | 0.76 | MEN1 (0.63) | MEN1KMT2ARAB9AALDH1A1GAA | |
| SCHEMBL8325463 | 0.76 | ACHE (0.63) | MEN1KMT2AALDH1A1GAAACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234615-A1 | 4-IMIDAZOLIDINONES AS KV1.5 POTASSIUM CHANNEL INHIBITORS | Wyeth LLC (US) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009079624-A1 | 4-IMIDAZOLIDINONES AS KV1.5 POTASSIUM CHANNEL INHIBITORS | WYETH (US) | 2009-06-25 | — | — | WO | disclosed |
| WO-2009079624-A1 | 4-IMIDAZOLIDINONES AS KV1.5 POTASSIUM CHANNEL INHIBITORS | WYETH (US) | 2009-06-25 | — | — | WO | disclosed |