Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 12/20 | 0.34 |
| ▸ | DRD3 | P35462 | 12/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 5/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.34 |
| ▸ | DRD1 | P21728 | 3/20 | 0.33 |
| ▸ | DRD5 | P21918 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3655498 | 0.92 | HSD11B1 (0.37) | HSD11B1DRD2DRD3HTR1DDRD4 | |
| SCHEMBL3032651 | 0.88 | RORC (0.42) | HSD11B1DRD2DRD3HTR1DDRD4 | |
| SCHEMBL3032654 | 0.88 | RORC (0.42) | HSD11B1DRD2DRD3HTR1DDRD4 | |
| SCHEMBL3023551 | 0.81 | HSD11B1 (0.31) | HSD11B1DRD2DRD3DRD4DRD1 | |
| SCHEMBL3024960 | 0.81 | RORC (0.43) | HSD11B1DRD2DRD3DRD4DRD1 | |
| SCHEMBL3024958 | 0.81 | RORC (0.43) | HSD11B1DRD2DRD3DRD4DRD1 | |
| SCHEMBL3023879 | 0.78 | CYP2D6 (0.36) | DRD1 | |
| SCHEMBL3020753 | 0.77 | DRD2 (0.48) | DRD2DRD3HTR1DDRD4DRD1 | |
| SCHEMBL3653345 | 0.73 | HSD11B1 (0.35) | HSD11B1 | |
| SCHEMBL8068746 | 0.72 | DPP4 (0.35) | DRD2DRD3DRD4DRD1DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2203454-A1 | TRICYCLIC HETEROCYCLIC DERIVATIVES | N.V. Organon (NL) | 2010-07-07 | — | — | EP | disclosed |
| WO-2009037220-A1 | TRICYCLIC HETEROCYCLIC DERIVATIVES | N.V. ORGANON (NL) | 2009-03-26 | — | — | WO | disclosed |