Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 2/20 | 0.40 |
| ▸ | BRAF | P15056 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | LDLR | P01130 | 2/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3654254 | 0.86 | EPHX2 (0.46) | POLBSMN1; SMN2RXFP1MEN1KMT2A | |
| SCHEMBL3653079 | 0.85 | RAB9A (0.50) | SMN1; SMN2MEN1KMT2AALDH1A1GAA | |
| SCHEMBL3652812 | 0.85 | PDE4D (0.40) | SMN1; SMN2RXFP1MEN1KMT2AALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL3653109 | 0.85 | RAB9A (0.45) | SMN1; SMN2MEN1KMT2AALDH1A1GAA | |
| SCHEMBL3653093 | 0.84 | CYP1A2 (0.36) | SMN1; SMN2KMT2ACYP2C19 | |
| Trifluoroacetic Acid SCHEMBL3657528 | 0.82 | RXFP1 (0.37) | RXFP1ALDH1A1CYP2C19 | |
| SCHEMBL3657515 | 0.81 | RAB9A (0.41) | SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL3650108 | 0.80 | GAA (0.48) | RXFP1CSF1RBRAFMEN1KMT2A | |
| SCHEMBL3658110 | 0.78 | KDM4E (0.44) | POLBSMN1; SMN2KMT2AALDH1A1GAA | |
| Trifluoroacetic Acid SCHEMBL3656228 | 0.78 | RAB9A (0.46) | TSHRSMN1; SMN2CSF1RBRAFMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212282-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009052065-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-04-23 | — | — | WO | disclosed |