SCHEMBL3658110

SCHEMBL3658110

CC1CCC[N+]1(c1ccc(NC(=O)COc2ccccc2)c(C(F)(F)F)c1)C1CCNC1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.44
KMT2A Q03164 1/20 0.44
HPGD P15428 1/20 0.42
SMN1; SMN2 Q16637 3/20 0.42
MAPT P10636 2/20 0.42
CYP1A2 P05177 2/20 0.42
CYP3A4 P08684 2/20 0.42
CYP2C9 P11712 2/20 0.42
CYP2C19 P33261 2/20 0.42
CYP2D6 P10635 1/20 0.42
HTT P42858 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
ALDH1A1 P00352 2/20 0.41
RAB9A P51151 4/20 0.41
NPC1 O15118 4/20 0.41
LMNA P02545 1/20 0.40
GAA P10253 2/20 0.39
POLB P06746 2/20 0.38
L3MBTL1 Q9Y468 1/20 0.36
MAPK1 P28482 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL3653064 0.98 KDM4E (0.42) KDM4EKMT2AHPGDSMN1; SMN2MAPT
Trifluoroacetic Acid SCHEMBL3651075 0.89 CYP1A2 (0.40) KDM4EKMT2AHPGDSMN1; SMN2MAPT
SCHEMBL3658726 0.89 CYP1A2 (0.44) KDM4EKMT2ASMN1; SMN2MAPTCYP1A2
Trifluoroacetic Acid SCHEMBL3655787 0.85 MLYCD (0.46) KDM4EKMT2AMAPTCYP1A2CYP2C19
Trifluoroacetic Acid SCHEMBL3659677 0.82 HRH3 (0.32) HRH3
SCHEMBL3654254 0.82 EPHX2 (0.46) KMT2ASMN1; SMN2MAPTCYP1A2CYP3A4
SCHEMBL3652812 0.81 PDE4D (0.40) KDM4EKMT2AHPGDSMN1; SMN2MAPT
Trifluoroacetic Acid SCHEMBL3652246 0.81 EPHX2 (0.43) KMT2ASMN1; SMN2MAPTCYP1A2CYP3A4
SCHEMBL3655451 0.78 TSHR (0.40) KMT2ASMN1; SMN2CYP2C19NPSR1ALDH1A1
Trifluoroacetic Acid SCHEMBL3657528 0.78 RXFP1 (0.37) CYP1A2CYP2C19CYP2D6ALDH1A1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2212282-A1 SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF Sanofi-Aventis (FR) 2010-08-04 EP disclosed
WO-2009052065-A1 SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2009-04-23 WO disclosed