Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CCR8 | P51685 | 3/20 | 0.38 |
| ▸ | BCL3 | P20749 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3656321 | 1.00 | KCNH2 (0.44) | KCNH2HRH3KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL3656273 | 0.88 | HRH3 (0.44) | KCNH2HRH3SMN1; SMN2LMNACCR8 | |
| SCHEMBL3651913 | 0.86 | BCL9 (0.41) | SMN1; SMN2RAB9AALDH1A1MAPT | |
| SCHEMBL3653649 | 0.86 | BCL9 (0.41) | SMN1; SMN2RAB9AALDH1A1MAPT | |
| SCHEMBL3658188 | 0.86 | BCL9 (0.41) | SMN1; SMN2RAB9AALDH1A1MAPT | |
| Trifluoroacetic Acid SCHEMBL3657521 | 0.82 | MEN1 (0.42) | KMT2ASMN1; SMN2RAB9AMEN1LMNA | |
| SCHEMBL3650108 | 0.81 | GAA (0.48) | KMT2ARAB9AMEN1KDM4EALDH1A1 | |
| SCHEMBL3657254 | 0.81 | SMN1; SMN2 (0.39) | SMN1; SMN2RAB9ALMNAALDH1A1NPC1 | |
| SCHEMBL3648133 | 0.80 | LMNA (0.41) | KMT2ASMN1; SMN2RAB9AMEN1LMNA | |
| SCHEMBL3658726 | 0.79 | CYP1A2 (0.44) | KMT2ASMN1; SMN2RAB9AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212282-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009052065-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-04-23 | — | — | WO | disclosed |