Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | PLAT | P00750 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.35 |
| ▸ | OXTR | P30559 | 1/20 | 0.35 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.35 |
| ▸ | CCR8 | P51685 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | BCL9 | O00512 | 1/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3653649 | 0.89 | BCL9 (0.41) | MAPTSMN1; SMN2BCL9CTNNB1 | |
| SCHEMBL3658188 | 0.89 | BCL9 (0.41) | MAPTSMN1; SMN2BCL9CTNNB1 | |
| SCHEMBL3651913 | 0.89 | BCL9 (0.41) | MAPTSMN1; SMN2BCL9CTNNB1 | |
| SCHEMBL3656206 | 0.88 | KCNH2 (0.44) | HRH3KCNH2TP53MAPTSMN1; SMN2 | |
| SCHEMBL3656321 | 0.88 | KCNH2 (0.44) | HRH3KCNH2TP53MAPTSMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL3656579 | 0.85 | BCL9 (0.37) | KCNH2AVPR2OXTRAVPR1ABCL9 | |
| SCHEMBL3657254 | 0.81 | SMN1; SMN2 (0.39) | MAPTSMN1; SMN2LMNABCL9CTNNB1 | |
| SCHEMBL3648133 | 0.80 | LMNA (0.41) | MAPTSMN1; SMN2KDM4ELMNABCL9 | |
| SCHEMBL3650108 | 0.80 | GAA (0.48) | GAAMAPTKDM4E | |
| SCHEMBL3654285 | 0.79 | MAPT (0.38) | MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212282-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009052065-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-04-23 | — | — | WO | disclosed |